Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose Interleukin 4 deficiency protects mice from acetaminophen induced liver injury and inflammation by prevention of glutathione depletion Inflammation Research Springer Nature Link An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Paracetamol metabolism. Download Scientific Diagram