Acetaminophen Toxicity Liver Damage Illustration The Case Severe high anion gap metabolic acidosis Kidney International Serotonin Deficiency Exacerbates Acetaminophen Induced Liver Toxicity In Mice Scientific Reports g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem