Glutathione for Acne: Does it Help? Moon Juice Ishin Is it purging po or breakout? Magkaiba po ang purging sa breakout.. Will you experience purging with Glutathione? Because Glutathione is detoxifying, you may experience the skin getting worse before Can Glutathione Cause Purging? Understanding the Connection Between Glutathione and Acne Breakouts Cymbiotika CYMBIOTIKA Can Glutathione Cause Purging? Understanding the Connection Between Glutathione and Acne Breakouts Cymbiotika CYMBIOTIKA Skin purging is a common, temporary skin breakout reaction to ingredients in certain skincare products, such as retinol and alpha hydroxy acids.