Can Collagen Cause Acne? What Science Actually Says How To Tell If You're Purging Or Breaking Out Most Common Signs Before you spend money on glutathione, read this first. Topical, oral, injectable what actually works and what's just marketing? #funskincare #funingredientsinfographic101 Skin purging is a common, temporary skin breakout reaction to ingredients in certain skincare products, such as retinol and alpha hydroxy acids. Why Does Glutathione Cause Acne Breakouts?