Most people learn about senescent cells from a podcast. I learned about them the hard way after pushing my body through the Grand Goals campaign and realizing that physical achievement doesn't mean FOXO4 DRI UK Senolytic Peptide Research Peptides Lab UK Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications