Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly Arteriosclerosis, Thrombosis, and Vascular Biology Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Acetaminophen toxicity EMCrit Project Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.