Pathology of G6PD deficiency Pathology Made Simple G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Metabolism: The pentose phosphate pathway and G6PD deficiency (practice) Khan Academy Glucose 6 Phosphate Dehydrogenase Deficiency Hematology & Oncology UWorld Medical Library Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society