The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications TRANSLATING THE BIOLOGY OF AGING INTO NEW THERAPEUTICS FOR ALZHEIMER'S DISEASE: SENOLYTICS The Journal of Prevention of Alzheimer's Disease BPC 157 Supports Recovery, Gut Health & Regeneration FOXO4 DRI Peptide: Support Healthy Cellular Aging
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