Treatment strategies for glucose 6 phosphate dehydrogenase deficiency: past and future perspectives: Trends in Pharmacological Sciences G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Loss of glucose 6 phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells PNAS Is Glutathione Safe for G6PD Deficiency? Understanding the Antioxidant Connection Cymbiotika CYMBIOTIKA Glucose 6 phosphate dehydrogenase (G6PD) deficiency X linked recessive Xq28 is not true recessive as heterozygotes can express the trait; G6PD > No NADPH > No RBC glutathione protection > free radical damage hemolysis